Table 1 Demographic characteristics of samples

From: Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers

Samples

Control

ADAD

sAD

Presym

Other

Total

9

16

31

3

8

MS4A (AG %)*

55.6

46.7

45.2

33.3

12.5

TREM2@

-

-

15

-

4

PSEN1

-

13

-

-

-

APP

-

3

-

-

-

Braak Aβ (0/A,B/C)

2/7/0

0/0/16

0/0/31

0/0/3

2/5/1

Braak Tau (NA/I-III/IV-VI)

0/9/0

3/0/13

4/2/25

0/0/3

0/6/2

Sex (XY)%

33.3

56.3

45.2

33.3

50.0

AOD (mean, sd)y

90.1(9.6)

51.0(6.9)

81.5(6.4)

77.3(15.3)

88.8(6.1)

APOEℇ4+ %$

11.1

25.0

54.8

33.3

12.5

PMI (mean, sd)h

10.9(5.5)

14.2(7.7)

11.9(6.3)

12.4(1.9)

11.3(9.1)

  1. Other: (1:Dementia with Lewy bodies, 4:Argyrophilic grain disease, 1:Tramatic encephalopathy, 1:Neurofibrillary tangle-predominant AD, 1:Cerebrovascular disease).
  2. ADAD autosomal dominant Alzheimer’s disease, sAD sporadic Alzheimer’s disease, Presym presymptomatic, PMI postmortem interval.
  3. *MS4A is referring to SNP rs1582763 (GG:25, AG:28, and AA:13).
  4. @Two African descent and one Asian descent (the p.H157Y is European descent).
  5. $The total number of APOE ℇ4+ were 24 (APOE genotypes: 23:4, 24:2, 33:39, 34:19, 44:3).
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