Fig. 4: vmPFC-NAcSh activity supports social approach behavior following social defeat. | Nature Communications

Fig. 4: vmPFC-NAcSh activity supports social approach behavior following social defeat.

From: Regulation of social interaction in mice by a frontostriatal circuit modulated by established hierarchical relationships

Fig. 4: vmPFC-NAcSh activity supports social approach behavior following social defeat.

a Experimental timeline and schematic of surgical strategy for viral injections for driving selective expression of hM4Di-mCherry inhibitory DREADDs or viral control in vmPFC-NAcSh cells. Created with BioRender.com b Heatmaps showing representative behavior of hM4Di-mCherry and viral control injected animals (unstressed controls, susceptible and resilient animals) after CNO injection. c Social interaction behavior (total interaction zone time) of stressed (susceptible (red) and resilient (blue)) hM4Di-expressing animals but not unstressed controls was significantly reduced by CNO injection but not viral control animals. Repeated measures two-way ANOVA (N = Unstressed: 5 viral control, 11 hM4Di; Stressed: 17 viral control, 15 hM4Di; 2 experiments), Bonferroni corrected for post-hoc comparisons, significant interaction F(1,44) = 6.71, *p = 0.013; Stressed viral control vs. stressed hM4Di: t(44) = 2.716, *p = 0.019; Unstressed viral control vs. unstressed hM4Di, t(44) = 1.317, p = 0.39). Error bars presented as mean ± SEM.

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