Fig. 1: Summary of the discovery screening. | Nature Communications

Fig. 1: Summary of the discovery screening.

From: The Trypanosoma cruzi Antigen and Epitope Atlas: antibody specificities in Chagas disease patients across the Americas

Fig. 1

The figure shows a schematic representation of the steps followed to analyse two T. cruzi proteomes (CL-Brener and Sylvio X10) using pooled serum samples across the Americas (one pool from Chagas-infected individuals and one from healthy subjects from Argentina, Brazil, Bolivia, Colombia, Mexico, and the United States). The numbers below each tube represent the number of individual sera in each pool. An additional pooled serum sample of Leishmania-infected individuals and their healthy counterparts were used to study cross-reactivity. The protein used for this example is the metacaspase 5 protein from Sylvio X10 (TCSYLVIO_006975), which has 291 residues and was represented in each array using 69 peptides (16mers with an offset of 4 aa), of which only the first 4 peptides are shown here. Third-party image elements: the coloured map was created with MapChart, tubes and person open-licensed clipart are from Pixabay and SVG Repo.

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