Fig. 4: Individual patient resolution and epitope mapping of Chagas disease antigens. | Nature Communications

Fig. 4: Individual patient resolution and epitope mapping of Chagas disease antigens.

From: The Trypanosoma cruzi Antigen and Epitope Atlas: antibody specificities in Chagas disease patients across the Americas

Fig. 4: Individual patient resolution and epitope mapping of Chagas disease antigens.The alternative text for this image may have been generated using AI.

Examples of different types of antibody-binding profiles obtained using CHAGASTOPE-v2 arrays. In all cases, the reactivity of the pooled samples in the CHAGASTOPE-v1 discovery screening is shown at the top (dark blue), and stacked plots of the reactivity of the same protein against individual serum samples are shown below. See Supplementary Data S2 for the codes of patient serum samples (MX = Mexico, CO = Colombia, US = United States). Source data are provided as a Source Data file. A Example antigen with a single reactive region, showcasing peptides with signal above threshold (and most reactive peptides in bold). B Non-repetitive antigen displaying multiple reactive peaks (marked using roman numerals), and the corresponding peak sequences below. C Repetitive antigen displaying heterogeneous recognition of the repetitive unit by different Chagas-positive individuals.

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