Fig. 5: Comparison of strain-specific antigenicity across subjects. | Nature Communications

Fig. 5: Comparison of strain-specific antigenicity across subjects.

From: The Trypanosoma cruzi Antigen and Epitope Atlas: antibody specificities in Chagas disease patients across the Americas

Fig. 5

Counts of each subject’s strain-specific reactive peptides (those present in only one strain and with a signal above the antigenicity threshold) were standardised using Z-scores. Standardisation was necessary because CL-Brener and Sylvio X10 strains have different numbers of encoded proteins (see Methods). Z-scores above 0 and below 0 represent the higher and lower relative numbers of strain-specific reactive peptides, respectively. See Supplementary Data S2 for the codes of patient serum samples (AR = Argentina, BR = Brazil, BO = Bolivia, CO = Colombia, MX = Mexico, US = United States). Samples that were not part of the discovery screening and hence were not used for antigen discovery and design of the CHAGASTOPE-v2 arrays are highlighted in yellow. Source data are provided as a Source Data file.

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