Fig. 6: Profiling of individual antibody responses reveals the diversity of anti-T. cruzi-specific antibodies. | Nature Communications

Fig. 6: Profiling of individual antibody responses reveals the diversity of anti-T. cruzi-specific antibodies.

From: The Trypanosoma cruzi Antigen and Epitope Atlas: antibody specificities in Chagas disease patients across the Americas

Fig. 6

A Histogram showing the number of clusters of antigenic regions that were reactive in each fraction of subjects (shown as seroprevalence). Sequence similarity to known antigens was assessed by BLASTP against T. cruzi linear epitopes in the IEDB (see Methods). Previously described antigens are shown in orange; antigens without matches to the IEDB are in light blue. B Inset zooming in on the 98 clusters reactive in at least 50% of the subjects (colours for novel and known antigens as in (A)). C Heatmap showing the percentage of non-redundant antigenic peptides that were shared between a pair of individual samples. The hierarchical clustering of samples shows three main branches (coloured and labelled at the sides) that correspond to the boxed peptide reactivities. A similar figure showing all sample labels is available, see Supplementary Fig. S4. Source data for each panel are provided as a Source Data file.

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