Fig. 1: Screening of repurposing chemical libraries identify several compounds that enhance or synergize caspofungin activity. | Nature Communications

Fig. 1: Screening of repurposing chemical libraries identify several compounds that enhance or synergize caspofungin activity.

From: A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi

Fig. 1: Screening of repurposing chemical libraries identify several compounds that enhance or synergize caspofungin activity.The alternative text for this image may have been generated using AI.

a Heat map of % of metabolic activity using Alamar blue. The % of activity is based on A. fumigatus grown for 48 hs at 37 °C in the absence or presence of a specific compound (MM + CAS [0.2 µg/mL] or MM + enhancers or synergizers alone [20 µM], or a combination of MM containing CAS [0.2 µg/mL]) and added of enhancer or synergizers [0.6–20 µM] divided by the control (MM), both grown for 48 h at 37 °C. The results are the average of three independent experiments analyzed in technical duplicates each. Heat map scale and gene identities are shown. b Chemical structures of the CAS synergizers.

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