Fig. 7: Fiber diameter in treated muscles. | Nature Communications

Fig. 7: Fiber diameter in treated muscles.

From: Correction of Clcn1 alternative splicing reverses muscle fiber type transition in mice with myotonic dystrophy

Fig. 7: Fiber diameter in treated muscles.

a We measured minimal Feret’s diameter, defined as the minimum distance between parallel tangents37, of tibialis anterior (TA) muscle fibers in LR41;Mbnl1−/− treated with Clcn1 ASO or invert oligo (N = 4 each). Untreated wild-type (WT; N = 3) served as controls. Diameter is displayed as % frequency for MyHC 2 A (upper left), MyHC 2X (upper right), and MyHC 2B (lower left) fibers. b Mean fiber diameter using data from a). ***P < 0.001; **P < 0.01; P < 0.05 (one-way ANOVA). Error bars indicate ±s.e.m. Source data are provided as a Source Data file.

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