Fig. 7: Injectable delivery of 3D LVD-cardiac tissue constructs. | Nature Communications

Fig. 7: Injectable delivery of 3D LVD-cardiac tissue constructs.

From: Leaf-venation-directed cellular alignment for macroscale cardiac constructs with tissue-like functionalities

Fig. 7

a Schematic of rolling up cardiac construct. b The rolled cardiac construct in the tubing. c In vitro injectability and shape recovery of the cardiac construct. d Injected cardiac construct on porcine heart. e The structural integrity of the injected cardiac construct. f The simulation results of the strain force distribution within the scaffold and fibrin hydrogel of the LVD-cardiac construct during the rolling process. g Quantification of the maximum strain force within the scaffold and fibrin hydrogel respectively, when the LVD-cardiac constructs were wrapped in different angles. h Fluorescence imaging of live (green) and dead cells (red) in LVD tissues before and after injection. Inset: lower-magnification image of LVD tissues. i Cell viability of cardiac constructs before and after injection. n = 3 independent samples. Data are represented as mean values ± standard deviation. The significant difference is determined by unpaired two-tailed t-test, 95% confidence interval. ns (p > 0.05) no significant difference.

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