Fig. 2: Results of TWASs of EAA and multivariate longevity.
From: Multi-omic underpinnings of epigenetic aging and human longevity
a–e Manhattan plots of gene-traits associations for aging-related traits (IEAA, GrimAge, HannumAge, PhenoAge, multivariate longevity). X axes represent genomic position. Blue lines represent Z = 4.837, which corresponds to a Bonferroni-corrected significance threshold of P = 1.32 × 10−6. Red circles represent statistically significant gene-trait associations. Statistical analyses were conducted using two-sided t-tests. f Venn diagram quantifying the overlapping genes shared by two or more aging-related phenotypes. Encircled numbers represent the number of significant genes shared between two or more phenotypes. TWAS transcriptome-wide association study, EAA epigenetic age acceleration, IEAA intrinsic epigenetic age acceleration.
