Fig. 3: Results of metabolome-wide MR analysis on multivariate longevity.

MR effects of metabolic phenotypes on multivariate longevity. Metabolic phenotypes with significant, positive Z scores (beta/standard error) are predicted to increase multivariate longevity and vice versa. The eight most significant positive and negative associations are labeled with abbreviated codes, and the full name corresponding to each code is contained in Supplementary Data 23. Green circles represent metabolic phenotypes that increase multivariate longevity and blue circles represent metabolic phenotypes that decrease multivariate longevity. The dotted line corresponds to a Bonferroni-adjusted significance threshold of P = 0.00122 (0.05/41 principal components). The full results of the metabolome-wide MR analysis, including estimates on EAA (all null), are contained in Supplementary Data 25–29. Statistical analyses were conducted using two-sided t-tests. MR Mendelian randomization, EAA epigenetic age acceleration.