Fig. 4: CELLECT-MAGMA cellular associations with EAA.
From: Multi-omic underpinnings of epigenetic aging and human longevity
a–d Results from CELLECT-MAGMA cell-type enrichment analysis of four EAA traits significant at a FDR of 0.05. Bars represent negative, log-transformed, unadjusted P values. The scRNA-seq data used in this analysis comes from the Tabula Muris database and encompasses 115 cell types from 20 Mus musculus tissues. The full results of the cell-type enrichment analyses, including CELLECT-LDSC results and cellular associations with multivariate longevity (all null), are contained in Supplementary Data 30–34. Statistical analyses were conducted using one-sided t-test tests. CELLECT CELL-type Expression-specific integration for Complex Traits; MAGMA Multi-marker Analysis of GenoMic Annotation, FDR false discovery rate, scRNA-seq single-cell RNA sequencing, LDSC linkage disequilibrium score regression.
