Fig. 2: Interactions between scaffolds and MCPs. | Nature Communications

Fig. 2: Interactions between scaffolds and MCPs.

From: Cryo-electron microscopy structures of capsids and in situ portals of DNA-devoid capsids of human cytomegalovirus

Fig. 2: Interactions between scaffolds and MCPs.

a Asymmetric reconstruction of the HCMV B-capsid with the front half of the capsid shell (gray) removed. The portal is in yellow and the three layers of scaffolds are colored as in Fig. 1a. b Cross-section of one-quarter of the B-capsid map, showing the radial distribution of the three layers of the scaffolds. Density map (c) and schematic (d) of one asymmetric unit of the icosahedral B-capsid, showing scaffold densities contacting with the capsid shell. The MCPs in center- (C-hexon), peripenton- (P-hexon), edge-hexons (E-hexon) and penton are in light blue, pink, medium purple and gold, respectively. The triplexes Ta to Te are in wheat, yellow, purple, cyan and magenta, respectively. e Enlarged view of the boxed region in (c), exemplifying that each of the nine patches of the outer shell scaffolds interacts with the capsid floor at the hydrophobic groove (inset. hydrophobic, gold; hydrophilic, cyan) formed by two neighboring MCPs. f Summary of the regions on MCPs associated with the nine patches of the outer shell scaffolds.

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