Fig. 5: Induction of S-specific IFN-γ positive T cells in BALB/c mice. | Nature Communications

Fig. 5: Induction of S-specific IFN-γ positive T cells in BALB/c mice.

From: Immunogenicity and protective efficacy of SARS-CoV-2 mRNA vaccine encoding secreted non-stabilized spike in female mice

Fig. 5

a mice were immunized with various doses of ChulaCov19 analyzed at 2 weeks after the second dose. b heterologous prime/boost study; mice were primed with CoronaVac or AZD1222 vaccine and boosted with ChulaCov19 (5 µg). Homologouse prime/boost results of each vaccine were included. S-specific IFN-γ positive T cells were determined in duplicate assays from 5 mice in each group. Bars represent the mean ± SD of S-specific IFN-γ positive T cells after stimulated with overlapping peptide pools spanning the SARS-CoV-2 S1 (pooled #1-5) and S2 (pooled #6-10). Statistical significance was determined by two-sided Mann–Whitney test. Differences were considered significant at p < 0.05 with exact p-values shown. p < 0.05 and p < 0.01 are indicated by * and **, respectively. SD; standard deviation. Source data are provided as a Source Data file.

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