Fig. 2: Structural modelling of mutations mapped to the spike RBD.
From: Generation of SARS-CoV-2 escape mutations by monoclonal antibody therapy
a Model of the Omicron RBD (7TLY) docked with S309 (sotrovimab). Omicron RBD is shown as a grey surface from an approximate front view, S309 as cartoon ribbons with heavy and light chains coloured separately. Mutation sites mapped to the RBD surface are coloured magenta and labelled. b Close-up view of the interface between the P337, E340, K356 patch of residues with the S309 heavy chain. Potential hydrogen bonds and hydrophobic interactions are shown as green dashed lines. c Model of the Delta RBD docked with REGEN-COV mAbs casirivimab and imdevimab shown from approximate front (left) and back (right) views. Delta RBD is shown as a grey surface and mutation sites E406, G446, Y453 and L455 are coloured magenta and labelled. d Close-up view of the interface between E406, Y453 and L455 with casirivimab. e Close-up view of the interface between G446 with imdevimab. Potential hydrogen bonds and hydrophobic interactions are shown as green dashed lines.
