Table 1 Patterns of cellular distribution according to histologic type (n = 225)

From: Immune cellular patterns of distribution affect outcomes of patients with non-small cell lung cancer

Panel

Phenotype

Pattern of malignant cellsa

P†

NSCLC

Adenocarcinoma

Squamous cell carcinoma

1

CD3 + 

27.96

25.05

38.86

0.942

CD3 + CD8 + 

25.81

24.03

31.92

0.902

CD3 + PD-1+

16.53

12.17

23.92

0.132

CD3 + PD-L1 + 

20.19

19.45

22.64

0.386

CD3 + CD8 + PD-1+

3.20

2.89

4.79

0.996

CD3 + CD8 + PD-L1 + 

11.07

10.82

13.02

0.769

CD68 + 

17.50

15.55

21.86

0.334

CD68 + PD-L1 + 

9.33

8.10

9.81

0.889

2

CD3 + 

27.30

22.98

37.84

0.933

CD3 + CD8 + 

29.88

27.20

37.36

0.644

CD3 + CD8 + GZB + 

0.36

0.04

0.89

0.372

CD3 + CD45RO + 

35.84

30.14

48.40

0.933

CD3 + CD8 + CD45RO + 

31.10

25.35

41.40

0.294

CD3 + CD8negFOXP3 + 

29.55

26.75

37.41

0.428

CD3 + CD45RO + FOXP3 + 

24.30

8.92

14.80

<0.001

3

CD3 + 

29.14

28.38

32.00

0.260

CD3 + B7-H3 + 

26.49

25.31

28.83

0.816

CD3 + PD-L1 + 

30.27

28.75

32.32

0.230

4

CD3 + 

21.00

20.33

28.00

0.633

CD3 + ICOS + 

12.00

11.59

14.00

0.647

CD3 + LAG3 + 

22.30

19.03

29.50

0.633

CD3 + OX40 + 

6.35

4.84

9.50

0.232

CD3 + TIM3 + 

4.07

5.22

3.00

0.261

CD20 + 

6.05

4.14

9.00

0.314

CD20 + ICOS + 

4.11

2.15

7.00

0.342

CD20 + OX40 + 

3.00

2.82

3.50

0.954

CD20 + LAG3 + 

10.89

8.95

15.50

0.280

5

CD68 + 

19.64

17.31

24.76

0.884

CD68 + CD11b + 

21.84

18.95

26.81

0.365

CD66b + 

3.54

2.13

6.32

0.186

CD11b + CD66b + 

4.00

2.54

8.50

0.720

CD11b + CD66b + CD33 + 

3.00

1.96

6.00

0.113

  1. Note: NSCLC, non-small cell lung cancer. For determining the patterns of distribution, 26 relevant cell phenotypes with densities >2 cell/mm2 were considered in the analysis according to NSCLC and histologic types, totalizing 78 results. In addition, the data was used to correlate with clinicopathologic variables.
  2. aA score of −10 to 10 indicates a mixed pattern, and a score >10 indicates an unmixed pattern.
  3. † P-values indicate comparison between adenocarcinoma and squamous cell carcinoma using Kruskal-Wallis test and un-adjusted P-values.
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