Table 2 Median distances from malignant cells for various cell phenotypes according to histologic type (n = 225)
From: Immune cellular patterns of distribution affect outcomes of patients with non-small cell lung cancer
Panel | Phenotype | Median distance from malignant cells, µm | P* | ||
|---|---|---|---|---|---|
NSCLC | Adenocarcinoma | Squamous cell carcinoma | |||
1 | CD3 + | 29.28 | 26.88 | 38.38 | 0.002 |
CD3 + CD8 + | 59.66 | 58.62 | 61.36 | 0.003 | |
CD3 + PD-1+ | 104.31 | 113.53 | 99.03 | 0.181 | |
CD3 + PD-L1 + | 105.56 | 105.02 | 105.56 | 0.870 | |
CD3 + CD8 + PD-1 | 220.89 | 245.71 | 203.72 | 0.163 | |
CD3 + CD8 + PD-L1 + | 218.69 | 218.69 | 216.45 | 0.551 | |
CD68 + | 42.01 | 44.52 | 37.57 | 0.168 | |
CD68 + PD-L1 + | 113.40 | 111.04 | 113.41 | 0.778 | |
2 | CD3 + | 30.42 | 27.66 | 42.28 | <0.001 |
CD3 + CD8 + | 60.40 | 54.07 | 78.40 | <0.001 | |
CD3 + CD8 + GZB + | 240.62 | 243.26 | 238.91 | 0.576 | |
CD3 + CD45RO + | 91.15 | 75.96 | 125.49 | <0.001 | |
CD3 + CD8 + CD45RO + | 140.69 | 114.36 | 186.28 | 0.001 | |
CD3 + CD8negFOXP3 + | 135.08 | 121.99 | 147.59 | 0.002 | |
CD3 + CD45RO + FOXP3 + | 252.20 | 221.84 | 281.49 | 0.013 | |
3 | CD3 + | 28.44 | 22.55 | 48.79 | <0.001 |
CD3 + B7-H3 + | 57.52 | 191.96 | 48.42 | 0.154 | |
CD3 + PD-L1 + | 125.09 | 135.49 | 115.57 | 0.203 | |
4 | CD3 + | 36.46 | 29.56 | 43.22 | 0.023 |
CD3 + ICOS + | 105.15 | 113.21 | 102.80 | 0.362 | |
CD3 + LAG3 + | 46.46 | 53.22 | 39.56 | 0.023 | |
CD3 + OX40 + | 201.04 | 233.01 | 184.20 | 0.019 | |
CD3 + TIM3 + | 256.75 | 295.88 | 230.01 | 0.007 | |
CD20 + | 104.61 | 118.82 | 91.79 | 0.060 | |
CD20 + ICOS + | 257.72 | 277.59 | 232.22 | 0.084 | |
CD20 + OX40 + | 305.35 | 353.03 | 266.19 | 0.041 | |
CD20 + TIM3 + | 448.24 | 453.10 | 444.30 | 0.436 | |
5 | CD68 + | 42.24 | 43.05 | 40.60 | 0.513 |
CD68 + CD11b + | 51.81 | 51.13 | 52.30 | 0.613 | |
CD66b + | 87.24 | 87.98 | 85.22 | 0.385 | |
CD11b + CD66b + | 133.49 | 121.79 | 141.08 | 0.358 | |
CD11b + CD66b + CD33 + | 214.99 | 199.89 | 217.28 | 0.864 | |
