Table 2 Summary of the main cis-regulatory grammar findings for each TFBS in heterotypic clusters

From: Transcription factor binding site orientation and order are major drivers of gene regulatory activity

Heterotypic

Order

Significant bias for proximal position: YY1, TFAP2C, ONECUT1, SP1, CREB1, AP1, FOXA1, CEBPA

Significant bias for distal position: RSRA, REST, HNF1A, XBP1,GABPA, NR2F2, CTCF, AHR, PPARA

Orientation

Significant strand biases in heterotypic pairs: PPARA, HNF4A, RXRA, REST, CEBPA, GABPA, AHR, HNF1A, YY1, AP1, TFAP2C, FOXA1, CTCF, XBP1, NR2F2, SP1, ONECUT1

Significant strand biases in heterotypic triplets: PPARA, REST, FOXA1, XBP1, HNF4A, CTCF, RXRA, AHR, CEBPA, TFAP2C, HNF1A, AP1, YY1, GABPA, ONECUT1, SP1, NR2F2

Triplet order

Significant order biases in heterotypic triplets: REST, HNF1A, CTCF, CREB1, GABPA, TFAP2C, SP1, AP1, NR2F2, XBP1, PPARA, ONECUT1, HNF4A, RXRA, FOXA1, CEBPA

Triplets orientation + Order

Significant order and strand biases in heterotypic triplets: SP1, NR2F2, ONECUT1, GABPA, YY1, HNF1A, AP1, TFAP2C, CEBPA, RXRA, CTCF, FOXA1, HNF4A, XBP1, REST, PPARA

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