Table 2 Performance of machine learning model to identify individuals who received autoantibody testing in the validation and external test datasets
Dataset | Total n | Autoantibody tested, n (%) | AUROC (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | Accuracy (95% CI) | NPV (95% CI) | PPV (95% CI) | F1 score |
|---|---|---|---|---|---|---|---|---|---|
Validation (BioMe cohort 1) | 25,062 | 5792 (23) | 0.93 (0.93 − 0.93) | 0.90 (0.90 − 0.90) | 0.87 (0.87 − 0.88) | 0.89 (0.88 − 0.89) | 0.90 (0.89 − 0.90) | 0.88 (0.87 − 0.88) | 0.89 (0.88 − 0.89) |
External test (All of Us) | 136,522 | 19,264 (14) | 0.87 (0.87 − 0.88) | 0.82 (0.82 − 0.83) | 0.82 (0.81 − 0.82) | 0.82 (0.82 − 0.82) | 0.82 (0.82 − 0.82) | 0.82 (0.82 − 0.82) | 0.83 (0.82 − 0.82) |
