Fig. 6: Mapping the PC-TP/FABP5–PPARδ interacting domains. | Nature Communications

Fig. 6: Mapping the PC-TP/FABP5–PPARδ interacting domains.

From: Ligand dependent interaction between PC-TP and PPARδ mitigates diet-induced hepatic steatosis in male mice

Fig. 6: Mapping the PC-TP/FABP5–PPARδ interacting domains.The alternative text for this image may have been generated using AI.

A Homology model of full-length PPARδ generated using the structure of full-length PPARy. Schema of the modular structure of PPARδ with representative domain truncations used in subsequent PCA experiments B, D To determine the locus of PPARδ interaction with PC-TP or FABP5, respectively, we utilized our nano-PCA in Huh7 cells (n = 6, one-way ANOVA, SEM). C, E TRIC experiments on 50 nm Cy5 NHS labeled PC-TP or FABP5 titrating in PPARδ Full-length (FL) or ligand-binding domain (LBD) (n = 3). Source data are provided as a Source Data file.

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