Fig. 6: The antitumour and postsurgical recurrence efficacy of NIL-IM-Lip + L in the B16F10 primary and postsurgical recurrence models. | Nature Communications

Fig. 6: The antitumour and postsurgical recurrence efficacy of NIL-IM-Lip + L in the B16F10 primary and postsurgical recurrence models.

From: Temperature sensitive liposome based cancer nanomedicine enables tumour lymph node immune microenvironment remodelling

Fig. 6: The antitumour and postsurgical recurrence efficacy of NIL-IM-Lip + L in the B16F10 primary and postsurgical recurrence models.The alt text for this image may have been generated using AI.

Mice were euthanized when the tumour volumes reached ~2000 mm3. a Schedule of the antitumour experiment in B16F10 tumour-bearing C57BL/6 mice. b Tumour volume curves of NS, IR780 + 1-MT + IL-15 + L, IL-IM-Lip, and NIL-IM-Lip+L treated B16F10 tumour-bearing C57BL/6 mice (n  =  6 biologically independent animals per group). c Photographs of tumours after 16 days of treatment (n  =  6 biologically independent animals per group). d Tumour weights in different formulation-treated groups (n  =  6 biologically independent animals per group). e The body weights of different formulation-treated mice (n  =  6 biologically independent animals per group). f Percent survival of different formulation-treated B16F10 tumour-bearing C57BL/6 mice (n  =  6 biologically independent animals per group). g Immunohistochemical images of tumour tissue sections (n  =  3 biologically independent experiments). Scale bar:50 μm. h Schedule of the antitumour postsurgical recurrence experiment on B16F10 tumour-bearing C57BL/6 mice. i Tumour volume curves of different formulation-treated B16F10 tumour-bearing C57BL/6 mice (n  =  5 biologically independent animals per group). j Images of mice during treatment in the antitumour postsurgical recurrence experiment. k, l Flow cytometric analysis of memory T cells from the spleens of mice after different treatments (n  =  3 biologically independent experiments per group). Data are presented as mean values ± SD. Statistical significances were calculated by one-way analysis of variance with Tukey’s post hoc test. **P < 0.01, ***P < 0.001, #P < 0.001. The statistical significances of b were calculated of the (12) (IR780 + 1-MT + IL-15 + L, (13) IL-IM-Lip+L, and (14) NIL-IM-Lip+L groups on day 15. Source data are provided as a Source Data file. N-IM-Lip+L NGR-IR780/1-MT-Lip+Laser NIL-I-Lip+L NGR/IL-15-IR780-Lip+Laser, IL-IM-Lip+L IL-15-IR780/1-MT-Lip+Laser.

Back to article page