Fig. 3: Established and emerging chemical design strategies employed to generate protein-based therapeutics. | Nature Communications

Fig. 3: Established and emerging chemical design strategies employed to generate protein-based therapeutics.

From: Engineering protein-based therapeutics through structural and chemical design

Fig. 3

a Site-specific mutagenesis. b Antibody-drug conjugates. c PEGylation. d Fc fusion. e Fusion to other proteins. f Glycosylation. g Lipidation. h Computational. i Supercharging. j Attachment of non-PEG polymers. k Fusion to other partners. l Unnatural amino acids. The structure shown in (h) represents neoleukin (NL)āˆ’2/15 (PDB ID: 6DG6) which is a predecessor to NL-201, the worldā€™s first de novo protein therapeutic.

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