Fig. 2: Chemical sensitivities of TRPV1s from tailed amphibians. | Nature Communications

Fig. 2: Chemical sensitivities of TRPV1s from tailed amphibians.

From: Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1

Fig. 2

a Response to capsaicin of TRPV1s from four tailed amphibians. Each TRPV1 was expressed in Xenopus oocytes and the capsaicin-induced response was examined by the two-electrode voltage clamp method. Voltage ramps from −100 mV to +100 mV were applied every 2 s and capsaicin was added at various concentrations. The I–V relationship for the max response at the indicated concentration of capsaicin is shown. The dose-response to capsaicin for each TRPV1 cDNA at −80 mV is summarized (n = 4 for each concentration of capsaicin). Each data point represents the mean ± SE. Source data are provided as a Source Data file. b Response to acid of TRPV1s from four tailed amphibians. Each TRPV1 was expressed in Xenopus oocytes and the acid-induced response was examined by the two-electrode voltage clamp method. Voltage ramps from −100 mV to +100 mV were applied every 2 s and acid at various concentrations were added. The I–V relationship for the max response at the indicated concentration of acid is shown. The dose–response to acid for each TRPV1 at + 80 mV is summarized (n = 4 for each pH). Each data point represents the mean ± SE. Source data are provided as a Source Data file.

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