Fig. 3: Substrate scope of the reaction. | Nature Communications

Fig. 3: Substrate scope of the reaction.

From: Design of C1-symmetric tridentate ligands for enantioselective dearomative [3 + 2] annulation of indoles with aminocyclopropanes

Fig. 3: Substrate scope of the reaction.The alternative text for this image may have been generated using AI.

Unless otherwise noted, reaction conditions are as follows: Ni(OTf)2/L4 (1:1.2, 5 mol%), 1 (0.2 mmol), 2 (0.44 mmol) in CH2Cl2 (4.0 mL) at 25 °C under N2 for 24 h. Isolated total yields for product 3 (both diastereoisomers) were reported. The dr value was determined by 1H NMR spectra of the crude product. The ee value was determined by chiral HPLC analysis. a Reaction conditions: 1a (0.3 mmol), 2a (0.66 mmol) in CH2Cl2 (6.0 mL). b Reaction time: 36 h. c Reaction conditions: Cu(OTf)2/L4 (1:1.2, 10 mol%) at 50 °C for 64 h. d Reaction temperature: 0 °C. e Reaction conditions: Cu(OTf)2/L4 (1:1.2, 10 mol%) at 35 °C.

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