Fig. 3: Error estimation for predicted antibody structures.
From: Fast, accurate antibody structure prediction from deep learning on massive set of natural antibodies
Reported Spearman correlation coefficients (ρ) are between predicted and calculated RMSD values with associated p values calculated according to a two-sided t-test. Source data are provided as a Source Data file. a Comparison of CDR H3 loop RMSD to predicted error for paired antibody structure benchmark. Gray space represents cumulative average RMSD of predicted CDR H3 loops from native structure. b Comparison of CDR3 loop RMSD to predicted error for nanobody structure benchmark. Gray space represents cumulative average RMSD of predicted CDR3 loops from native structure. c Predicted structure and error estimation for anti-HLA antibody with a randomized CDR H1 loop. d Predicted structure and error estimation for benchmark target 7O4Y (LH3 = 12 residues). e Predicted structure and error estimation for benchmark target 7RKS (LH3 = 18 residues). f Predicted structure and error estimation for benchmark target 7O33 (LH3 = 3 residues).
