Fig. 2: Analysis of the 1000 best-performing ADS sequences.
From: A massively parallel screening platform for converting aptamers into molecular switches
a Histogram of the frequency with which each base-position within the ATP aptamer was complementary to an SD sequence. This analysis was based only on the longest complementary region for each SD, with complementary regions of <3 nucleotides discarded. Nucleotides at each position in the aptamer are labeled above the histogram. Source data are provided as a Source Data file. b Histogram of Smith-Waterman similarity distances between the ATP aptamer and the reverse-complement of the top 1000 SDs from our screen. Source data are provided as a Source Data file. c Secondary structure of the ATP aptamer as previously discovered via NMR29. Boxed regions m1, m2, and m3 indicate segments complementary to the three recurring SD motifs that we identified.
