Fig. 1: The V3-glycan targeting DH270 broadly neutralizing antibody clone. | Nature Communications

Fig. 1: The V3-glycan targeting DH270 broadly neutralizing antibody clone.

From: Structural basis for breadth development in the HIV-1 V3-glycan targeting DH270 antibody clonal lineage

Fig. 1

A (upper left) A DH270 antibody Fab bound HIV-1 Envelope (Env) ectodomain highlighting the gp120 (blue) and gp41 (orange) subunits. Antibody Fab heavy and light chains are colored red and grey, respectively, with epitope glycans depicted in stick representation. (right) Zoomed-in, top and side views of the paratope-epitope contacts. Dashed circles indicate distinct contact regions. (lower left) Number indicators identify contact sites highlighted by the dashed circles in the panels to the right. B The inferred DH270 clone phylogenetic tree depicting cryo-EM maps determined for each clonal member Fab bound to the CH848 d949 trimer (white). The clonal member names are colored according to the Fab color of each map. Black numbering indicates locations of consequential mutations in each antibody according to sites listed in A. Affinities for antibodies on the path leading to the most broad and potent mature form, M6, are indicated in pink. Intermediate clonal members are denoted with an I while mature antibodies are denoted with an M.

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