Fig. 6: The I2 to I1, DH270.4, DH270.5, and DH270.6 transition. | Nature Communications

Fig. 6: The I2 to I1, DH270.4, DH270.5, and DH270.6 transition.

From: Structural basis for breadth development in the HIV-1 V3-glycan targeting DH270 antibody clonal lineage

Fig. 6

A DH270 clonal tree highlighting the I2 and I1 intermediate antibodies and the mature DH270.4 (M4), DH270.5 (M5), and DH270.6 (M6) antibodies. B Top views of the I1, DH270.4, DH270.5, and DH270.6 contact sites. Alpha-carbons (Cα) of heavy and light chain mutations are presented as spheres. C Structure of the I1 VH/VL contacts with the N332-glycan D1 arm showing the positions of the VL N62H and R56W mutations. D Structure of the DH270.4 heavy chain showing the position of possible contact between the S85F mutation and the N156-glycan. E Structure of the DH270.5 VH/VL mutations proximal to the N301-glycan. F Structure of the DH270.6 VH/VL mutations proximal to the N301-glycan. G Structure of the DH270.6 VL mutations proximal to the N442-glycan. H Structure of the DH270.6 VH shows two different states of the gp120 V1 loop.

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