Fig. 7: Envelope-DH270 clone structural coevolution. | Nature Communications

Fig. 7: Envelope-DH270 clone structural coevolution.

From: Structural basis for breadth development in the HIV-1 V3-glycan targeting DH270 antibody clonal lineage

Fig. 7

A Timeline of antibody and Env coevolution. The upper boxes indicate whether Envs at each time point are sensitive (green) or resistant to early intermediates (upper) and later intermediates/mature (lower) clonal members. Periods of infection at which long V1 loops are dominant are shown in grey with key mutation time points are highlighted along the timeline axis. Env structures were determined for sequences isolated at days 358, 526, 836, and 949 post infection highlighted on the timeline axis with period at which the D270 clone appeared highlighted. B (left) Side view of a single gp120/gp41 protomer highlighting the V1 and V3 GDIR/K motif. (right) V1 loop structures of each Env isolate. C (left) Top view of a single gp120/gp41 protomer highlighting the V1 and V3 GDIR/K motif. Maps and structure fits for the unliganded d358 (middle left), unliganded d949 (middle right), and I3 bound d949 (right) structures. D The I3 (left) and I2 (right) bound structures showing similarity in epitope conformation. E The DH270.6 bound d526 structure (left) and DH270.6 bound d949 structure (right) showing similarity in epitope conformation.

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