Fig. 2: Transcriptome analyses of the synergistic effect of TRPV1 blockade with thermotherapy. | Nature Communications

Fig. 2: Transcriptome analyses of the synergistic effect of TRPV1 blockade with thermotherapy.

From: Nanoparticle-mediated TRPV1 channel blockade amplifies cancer thermo-immunotherapy via heat shock factor 1 modulation

Fig. 2: Transcriptome analyses of the synergistic effect of TRPV1 blockade with thermotherapy.The alternative text for this image may have been generated using AI.

a Heat map of prominently upregulated and downregulated genes in A549-WT cells treated with the hyperthermia from CuS-NCs (0.2 mM) under light irradiation at the dose of 20.0 nM SB705498 (n = 3, fold change ≥ 2 and p < 0.05). b The number of variable primary transcripts between PBS and TRPV1 blockade-synergized thermotherapy. c Gene Ontology (GO) analysis of variable genes associated with the biologic process (red font), cellular component (blue font) and molecular functions (purple font) between PBS and TRPV1 blockade-synergized thermotherapy. d Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) algorithm analysis of functional interaction network between PBS and TRPV1 blockade-synergized thermotherapy. e Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of variable genes in A549-WT cells treated with TRPV1 blockade-synergized thermotherapy. The measurements were repeated 3 times. Statistical significance was determined by two-tailed Student’s t test (a) and two-tailed Fisher’s exact test (e). The raw RNA-sequencing data have been deposited in the Gene Expression Omnibus under the accession number GSE199299.

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