Fig. 5: USP7 expression during human embryonic pancreas development.
From: USP7 controls NGN3 stability and pancreatic endocrine lineage development
a UMAP projection of pancreatic epithelial cells in OMIX236 human fetal pancreas dataset. Cells are colored by assigned clusters. b UMAP projection of pancreatic epithelial cells. Cells are colored by developmental timepoints. c Co-expression of NEUROG3 (red) and USP7 (blue) across the scRNA-seq dataset. d Expression of NEUROG3, USP7, and PDX1 across developmental timepoints in NEUROG3-expressing clusters (EP, alpha, beta, delta, and pancreatic polypeptide) in the OMIX23634 scRNA-seq dataset. e UMAP projection of endocrine cells in OMIX236 human fetal pancreas dataset. Cells are colored by assigned clusters. f Co-expression of NEUROG3 (red) and USP7 (blue) across the endocrine clusters of the scRNA-seq dataset. g Expression of NEUROG3, USP7, and PDX1 across each NEUROG3-expressing cluster in the endocrine clusters of the scRNA-seq dataset. h Percentage of USP7+ cells across developmental timepoints in all NEUROG3-negative cells of the endocrine clusters. i Percentage of USP7+ cells across developmental timepoints in all NEUROG3-positive cells of the endocrine clusters.
