Fig. 1: Characterization of circRNAs in non-response and response group to ICB treatment in two cohort. | Nature Communications

Fig. 1: Characterization of circRNAs in non-response and response group to ICB treatment in two cohort.

From: Identification of CircRNA signature associated with tumor immune infiltration to predict therapeutic efficacy of immunotherapy

Fig. 1: Characterization of circRNAs in non-response and response group to ICB treatment in two cohort.The alternative text for this image may have been generated using AI.

Combination of four computational tools to identify back-splice junction reads from total RNA sequencing data in melanoma patients with ICB treatment in cohort 1 (a n = 70) and cohort 2 (b n = 69). The x-axis indicates the tumor samples, sorted by treatment category, time point, treatment efficacy, and junction reads calculated by the four tools. Number of identified circRNAs for each tool in cohort 1 (c) and cohort 2 (d). Number of identified circRNAs for each sample and generated from host gene in cohort 1 (e, g) and cohort 2 (f, h). i The overlap of identified circRNAs between cohort 1, cohort 2 and public circRNA database cicrAtlas and MiOncoCirc. BS, back splice. Source data are provided as a Source data Fig. 1a, b, e–h.

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