Fig. 5: Inferior immunity-dependent health outcomes associated with immune health grades (IHGs) that correspond to the immunologic resilience (IR) erosion-susceptible phenotype.

a Female sex workers (FSWs) stratified first by baseline behavioral activity score (BAS) and then by subsequent HIV seroconversion status. b Odds ratio (OR) with 95% confidence interval (CI) of having IHG-III or IHG-IV at baseline (purple) or future HIV seroconversion (blue) in FSWs according to baseline BAS and total sexually transmitted infection (STI) score. Far right, OR for HIV seroconversion by baseline IHG. c Associations of CD8-CD4 disequilibrium grades IHG-III and IHG-IV with age and sex; inducers of these grades; and outcomes. Findings are from the literature survey (also see Supplementary Table 2 for details and references) and our primary datasets. Flu, influenza; CMV, cytomegalovirus; MSW, men who have sex with men; ^&, interquartile range for age. ^†The original data from¹⁰⁶ stratified the CD4:CD8 ratio as ≤1.0 and >1.0. d–f Models depicting risk of indicated outcomes is lower in persons with the IR erosion-resistant phenotype (IHG-I). d HIV-AIDS, (e) COVID-19, and (f) recurrent cutaneous squamous cell cancer (CSCC) in renal transplant recipients. Pie charts depict relative proportions of the IHGs in the study group. Risk scaled from 1 to 3. Ag, antigenic; VL, viral load. *P < 0.05; **P < 0.01; ***P < 0.001; ns nonsignificant. Two-sided tests were used. Statistics are outlined in Supplementary Information Section 11.3.5., P values are in Supplementary Data 14, and Source data are provided as a Source Data file.