Fig. 1: Overall architecture of the SIN3B apo complex.
From: Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex
a Schematics showing domains and functional regions on the subunits of the SIN3B complex represented in linear form. SIN3B subunits are SIN3B (blue), HDAC2 (wheat), MORF4L1 (teal) and PHF12 (warm pink). Disordered parts of the complex are represented with fading colours. The PHF12ΔC-terminus construct used in the SIN3B complex sample lacks the poorly conserved and unstructured C-terminus (as observed in our EM analysis) and it ends at residue 502. b Cryo-EM density of the SIN3B full-length (SIN3BFL) sample at 3.4 Å resolution. c–f Cartoon representations of three main views of the SIN3B complex showing the overall architecture of the complex. Zinc (Zn) and calcium (Ca) cations are depicted and shown in shades of grey. HDAC2 is represented as surface in (d)–(f). SIN3B is represented as surface in (e).
