Table 1 Baseline characteristics of imaging subcohort

From: Genetics implicates overactive osteogenesis in the development of diffuse idiopathic skeletal hyperostosis

 

UK biobank cohort baseline visit (2008–2010)

Imaging subcohort baseline visit (2008–2010)

Imaging subcohort first imaging visit (2014+)

n

502,604

40,346

40,346

Age (years)

56.3 (8.1)

55.0 (7.5)

63.7 (7.6)

% Females

54.40%

51.70%

51.70%

BMI

27.43 (4.80)

26.54 (4.40)

26.61 (4.80)

Smoker (current)

10.50%

6.36%

3.55%

Smoker (previous)

34.50%

32.96%

33.84%

Comorbidities

% Hypertension

7.88%

6.44%

16.83%

% T1D

0.42%

0.26%

0.38%

% T2D

1.83%

1.57%

3.86%

% CKD

0.13%

0.71%

1.96%

% Dorsalgia

15.56%

10.31%

15.01%

% Scoliosis

0.81%

0.32%

0.49%

% Ankylosing Spondylitis

0.41%

0.21%

0.32%

% Kyphosis

0.19%

0.02%

0.05%

% Spondylosis

0.07%

0.03%

0.04%

% Knee Osteoarthritis

8.72%

1.38%

3.96%

% Hip Osteoarthritis

5.07%

0.20%

0.62%

% DISH EHR

0.0085%

0.0024%

0.0024%

Biomarkers

Glucose (mmol/L)

5.12 (1.24)

4.99 (1.24)

 

HbA1c (mmol/mol)

35.2 (6.78)

35.0 (6.78)

 

Trig (mmol/L)

1.75 (1.45)

1.65 (1.03)

 

LDL (mmol/L)

3.56 (0.87)

3.58 (0.87)

 

HDL (mmol/L)

1.45 (0.38)

1.47 (0.38)

 

Cholesterol (mmol/L)

5.69 (1.14)

5.72 (1.14)

 

Serum Phosphate (mmol/L)

1.16 (0.16)

1.16 (0.16)

 

Serum Calcium (mmol/L)

2.38 (0.09)

2.38 (0.09)

 

Serum Creatinine (umol/L)

72.31 (18.55)

72.34(18.55)

 

Cystatin C (mg/L)

0.91 (0.18)

0.87 (0.12)

 

VitD3 (nmol/L)

48.61 (21.11)

49.73 (21.11)

 
  1. Baseline characteristics of the UK Biobank cohort and the imaging subcohort. The following second level ICD10 codes from the electronic health records of all participants were used to identify the number of participants with different comorbidities prior to the appropriate visit to the center: I10 - Hypertension, E10 - Type 1 Diabetes (T1D), E11 - Type 2 Diabetes (T2D), N18 - Chronic Kidney Disease (CKD), M54 - Dorsalgia, M41 - Scoliosis, M45 - Ankylosing Spondylitis, M40 - Kyphosis, M47 - Spondylosis, M17 - osteoarthritis of knee, and M16 - osteoarthritis of hip. BMI body mass index, HbA1c - glycated hemoglobin, Trig triglycerides, LDL low density lipoprotein, HDL high density lipoprotein. The imaging cohort revisited the centers for imaging ~8 years after the baseline visit for all UK Biobank cohort participants.
Back to article page