Fig. 5: Distribution and enrichment analysis of Cluster of Orthologous Group of proteins (COG) of differentially expressed genes.

X-axis indicates the number of genes in the regions of unique interactions (a), unique chromosomal interaction domains (b), and unique insulation areas (c) were analyzed. Significant gene enrichment in a specific functional category is indicated by a single asterisk (the P values less than 0.05 are labeled; two-sided Fisher’s exact test). All P values are provided in the data source file. COG functional categories: [C], Energy production and conversion; [D], Cell cycle control, cell division, chromosome partitioning; [E], Amino acid transport and metabolism; [F], Nucleotide transport and metabolism; [G], Carbohydrate transport and metabolism; [H], Coenzyme transport and metabolism; [I], Lipid transport and metabolism; [J], Translation, ribosomal structure and biogenesis; [K], Transcription; [L], Replication, recombination and repair; [M], Cell wall/membrane/envelope biogenesis; [N], Cell motility; [O], Posttranslational modification, protein turnover, chaperones; [P], Inorganic ion transport and metabolism; [Q], Secondary metabolites biosynthesis, transport and catabolism; [R], General function prediction only; [S], Function unknown; [T], Signal transduction mechanisms; [U], Intracellular secretion, trafficking, and vesicular transport; [V], Defense mechanisms.