Fig. 4: Factor-associated loci converge on T cells. | Nature Communications

Fig. 4: Factor-associated loci converge on T cells.

From: Cross-disorder genetic analysis of immune diseases reveals distinct gene associations that converge on common pathways

Fig. 4

MAGMA gene-property results of Onek1k PBMC dataset (a) and tonsillar cells (b). The barplot shows −log10(p value) of the enrichment. P values were estimated using MAGMA, using a one-sided test. Colours in the barplot represent groups of cells belonging to the same cell type. The heatmap shows regression coefficients from the MAGMA model. c The bar plot shows the −log10(p-adjusted) of the top five GO terms enriched in factor-associated genes. P values were calculated with the hypergeometric test and corrected for multiple testing with the gprofiler-g:SCS. Blue, green and red represent the GO terms for Fgut, Faid and Falrg respectively. d The stacked-bar plot shows the number of genes unique or shared by the latent factors in the top 10 shared enriched GO terms. Grey represents genes unique to one of the factors, purple represents genes that are associated with two factors and orange represents genes that are associated with all three latent factors.

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