Fig. 1: Cryo-EM based models of TFIIH in apo state, holo-PIC and NER-TFIIH reveal how this multifaceted assembly reorganizes with changed functional context. | Nature Communications

Fig. 1: Cryo-EM based models of TFIIH in apo state, holo-PIC and NER-TFIIH reveal how this multifaceted assembly reorganizes with changed functional context.

From: Dynamic conformational switching underlies TFIIH function in transcription and DNA repair and impacts genetic diseases

Fig. 1: Cryo-EM based models of TFIIH in apo state, holo-PIC and NER-TFIIH reveal how this multifaceted assembly reorganizes with changed functional context.The alternative text for this image may have been generated using AI.

Anterior and posterior view of TFIIH in a the holo-PIC assembly; b apo-TFIIH; and c the NER lesion scanning complex. XPD anchor (light green), BSD2 (light blue) and ATP-cap (gold) elements of p62 positioned on the XPD surface in d PIC-TFIIH; e apo-TFIIH; and f NER-TFIIH. The TFIIH subunits are shown in cartoon representation colored as follows: XPD dark red, p62 blue, p44 orange, p34 green, p52 purple, p8 dark cyan, XPB pink; MAT1 and XPA are shown in tan and DNA is cyan.

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