Fig. 7: Therapeutic effect of NKCOF-12 on CKD mice. | Nature Communications

Fig. 7: Therapeutic effect of NKCOF-12 on CKD mice.

From: Efficient selective removal of uremic toxin precursor by olefin-linked covalent organic frameworks for nephropathy treatment

Fig. 7: Therapeutic effect of NKCOF-12 on CKD mice.

a Kidney weight index of mice in different groups (n = 6). b Serum Cr level of mice in different groups (n = 6). c Serum BUN levels of mice in different groups (n = 6). d Serum IS level of mice after drug intervention for 8 weeks (n = 6). e Collagen fiber area percentage of kidney measured by Masson staining (n = 3). a Data were represented as the mean ± SD. b, c Data presented as box-and-whisker plots, whiskers represent minima and maxima. * P < 0.05, **P < 0.01, ***P < 0.001, ns: no significance. Statistics were calculated by one-way ANOVA followed by Tukey’s post-test. Exact P values are given in the Supporting Information file.

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