Fig. 1: Overall crystal structure of the X0-afucosylated IgG1 complex.
From: Mechanism of glycoform specificity and in vivo protection by an anti-afucosylated IgG nanobody
a Side-view (left) and top-view (right) of the complex with transparent surfaces of afucosylated IgG1 Fc (purple) and superimposed cartoons of X0 (teal) shown. N-glycans are shown as sticks in dark purple. b Unbound X0 (aquamarine) and X0 in complex (teal) superimposed, with sticks of apical CDR3 loop sidechains shown. c Overlay of CDR3 loops only with coloring the same as in b. Distances between alpha carbons of indicated sidechains shown, demonstrating an induced fit.
