Fig. 6: Overview schematic of the allosteric signal transduction in CAPsen designs. | Nature Communications

Fig. 6: Overview schematic of the allosteric signal transduction in CAPsen designs.

From: Computational design of dynamic receptor—peptide signaling complexes applied to chemotaxis

Fig. 6: Overview schematic of the allosteric signal transduction in CAPsen designs.The alt text for this image may have been generated using AI.

Signal transduction pathways calculated by AlloDy from peptide-contacting residues (orange circles). The allosteric pathways utilize a diversity of receptor pocket residues to communicate information, but ultimately propagate the activation signals through a common set of allosteric determinants in the core of the receptor (yellow circles: F872.53, L1203.36, H2035.42, W2526.48, N2987.49). (See Figs. S7–S10 for a complete mapping of the allosteric couplings.) Receptor–peptide variants are shown in increasing order of conformational dynamism of the complexes: a the Csel2:Y7L complex, b the Csedy:V3Y-Y7L complex, c the WT CXCR4–CXCL12 complex, and d the Cdyn:V3Y complex.

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