Fig. 4: Additional time-resolved 2D ssNMR spectra of Aβ40 assemblies.
From: Early events in amyloid-β self-assembly probed by time-resolved solid state NMR and light scattering
a 2D 13C-13C ssNMR spectra of frozen Aβ40-VAG solutions with the indicated values of the evolution time τe. 2D spectra were recorded with 20 ms mixing periods. Horizontal and vertical lines indicate positions of crosspeak signal maxima that differ between spectra at τe = 0 (cyan lines) and τe > 0 (gold lines). Contour levels increase by factors of 1.2. b Heat map plot of differences in crosspeak intensity patterns, quantified by rmsd values, for all pairs of 2D ssNMR spectra. Values are normalized to the maximum rmsd. Only off-diagonal intensities in the aliphatic-aliphatic regions of the 2D spectra are included. c Same as b, but for carbonyl-aliphatic regions of the 2D spectra. Source data are provided as a Source data file.
