Fig. 4: The Neural Tourniquet.
From: Vagus nerve stimulation primes platelets and reduces bleeding in hemophilia A male mice
Electrical vagus nerve stimulation harnesses acetylcholine-secreting ChAT+ T lymphocytes in the spleen to stimulate platelet calcium uptake and alpha granule secretion via an α7nAChR-dependent mechanism. Vagus nerve stimulation primes circulating platelets to increase local thrombin production that accelerates clotting and reduces bleeding at sites of tissue injury.
