Fig. 1: Efflux pump gene amplifications and sdrM polymorphisms are widespread in independently evolved populations. | Nature Communications

Fig. 1: Efflux pump gene amplifications and sdrM polymorphisms are widespread in independently evolved populations.

From: Efflux pump gene amplifications bypass necessity of multiple target mutations for resistance against dual-targeting antibiotic

Fig. 1

The presence of mutations in genes encoding DNA gyrase subunits (gyrA, gyrB) and DNA topoisomerase IV subunits (parC, parE), the three mutant alleles sdrM1*, sdrM2*, and sdrM3*, and a genomic amplification containing sdrM, are shown for populations from intermediate passages, as well as the three isolates from the terminal passage, for the ten independently evolved populations. For each independent population, earlier to later passages are shown from left to right. Blue or yellow squares show the presence of the mutation (SNP or amplification) in a population or a terminal isolate, respectively. The terminal DLX concentrations represent the final concentrations of the evolution experiment (at which point the isolates were obtained).

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