Fig. 1: In vivo allergen challenge model to investigate mechanisms of local immune responses in human skin. | Nature Communications

Fig. 1: In vivo allergen challenge model to investigate mechanisms of local immune responses in human skin.

From: Impaired expression of metallothioneins contributes to allergen-induced inflammation in patients with atopic dermatitis

Fig. 1

A Human in vivo allergen challenge set-up. 6 mm biopsies taken 48 h after application of control and HDM (challenge) patch are processed to investigate transcriptional networks and regulatory interactions underpinning T cell-mediated responses to allergen. B Representative images of non-reactive, irritant, and reactive patch test responses to control (left) and HDM (right) allergen, 48 post-patch application. Number of patients in each group given. TEWL trans epidermal water loss, SPT skin prick test, FLG Filaggrin status, CR control patch reactive patient, HR HDM patch, reactive patient, CNR control patch, non-reactive patient, HNR HDM patch, non-reactive patient.

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