Fig. 2: Preparation and characterization of MTHMS.
a Synthesis routes of MTHMS. b Representative EDS element mapping of tvHMS (n = 3 independent experiments). Scale bar, 100 nm. c Representative transmission electron microscope (TEM) images of (i) solid silica, (ii) solid silica@tMS, (iii) tvHMS, and (iv) MTHMS (n = 3 independent experiments). Scale bar, 100 nm. d Diameter distribution and zeta potential of tvHMS and MTHMS through DLS (n = 3 independent experiments). Data represent the mean ± SD. e Representative UV-vis spectra of tvHMS, MnCO, TSSI, and MTHMS (n = 3 independent experiments). f Representative PL spectra of MTHMS (1 × 10−5 M TSSI) (n = 3 independent experiments). g Representative photoacoustic images of MTHMS (n = 3 independent experiments). h Representative UV-vis spectra of DTNB for the detection of GSH depleting ability of tvHMS (n = 3 independent experiments). i H2S production from tvHMS dispersed in GSH solution (n = 3 independent experiments). j Representative detection results of H2S production from tvHMS in GSH solution by Pb(NO3)2 soaked circular paper (n = 3 independent experiments). k Time-dependent TSSI release from MTHMS in GSH solution (n = 3 independent experiments). l Representative TEM images of MTHMS under GSH stimulus (n = 3 independent experiments). Scale bar, 100 nm. m Representative measurement of ROS production of MTHMS (1 × 10−6 M TSSI) under NIR irradiation (n = 3 independent experiments). n Representative thermographic images and (o) temperature change curves of H2O, MHMS, THMS, and MTHMS (1 × 10−4 M TSSI) after NIR exposure (660 nm, 0.3 W cm−2) (n = 3 independent experiments). p Representative measurement of CO generation at 37 °C after various treatments (n = 3 independent experiments). Source data underlying d–f, h, i, k, m, o, p are provided as a Source Data file.
