Fig. 1: Association of different aspects of psychosomatic health with tyrosine hydroxylase (TH) expression in the human fracture hematoma and outcome after upper ankle fracture.

a Correlational analyses of TH immunoreactivity in the fracture hematoma of human patients suffering upper ankle fracture with different aspects of psychosomatic health assessed by established questionnaires (somatic symptoms: Som, PHQ15; anxiety: Anx, GAD7; depression: Depri, PHQ9; stress load: Stress, PHQS; social functioning: socfunct, SF36; pain: SF36; childhood adversity: CTQ sum) on the days after the surgery. b Representative images (scale bars: 50 µm) visualizing TH immunofluorescent stainings in the fracture hematoma of a patient with low (0; left panel) and high (5; right panel) stress scores. n_{human patients} = 20–21. c Representative images (scale bars: 50 µm) visualizing TH and CD16 immunofluorescent double-stainings in the fracture hematoma of a patient with low (0; left panel) and high (5; right panel) stress scores. Fluorescent channels were adjusted equally for both groups. d Correlational analyses of TH immunoreactivity in the fracture hematoma at the day of surgery with the degree of mobility limitation, as well as the healing process impairment documented both at 3, 6, 9 and 12 months post surgery using visual analog scales (VASs). e Correlational analyses of different aspects of psychosomatic health assessed by established questionnaires (somatic symptoms: Som, PHQ15; anxiety: Anx, GAD7; depression: Depri, PHQ9; stress load: Stress, PHQS; social functioning: socfunct, SF36; pain: SF36; childhood adversity: CTQ sum) on the days following surgery with pain assessed by SF36 questionnaire at 3, 6, 9 and 12 months post surgery. Spearman correlation analyses, *P ≤ 0.05; **P ≤ 0.01, ***P ≤ 0.001 as significant correlation. n_{human patients} = 16 for the follow-up time points. Source data, exact n-numbers, exact p-values and used statistical tests per panel are provided in the Source Data file.