Fig. 5: The model of the Pol V transcription elongation-coupled DNA methylation.
From: A cryo-EM structure of KTF1-bound polymerase V transcription elongation complex
The structure of KTF1-bound Pol V TEC indicates that the C-terminal GW motifs of both KTF1 and NRPE1 point to the upstream direction of Pol V, allowing recruitment of siRNA-loaded AGO4/6 in the upstream of Pol V transcription. ‘M’ stands the methyl modification on DNA.
