Fig. 1: Detection of single amino acids in MoS₂ nanopores.

a Schematic of the experimental setup (not to scale). Amino acids are electrophoretically driven through a MoS₂ nanopore. b An example trace recorded with the addition of 2 μM E in a ~1.1 nm nanopore (Device #1) and a typical current blockade selected from the trace (marked by pentagram). c An example trace recorded with the addition of 2 μM A in a ~0.5 nm nanopore (Device #2) with the current histogram. The bimodal distribution is from the baseline current and the blockade current. d Heatmap of dwell time versus current blockade of G, GG, and GGG, respectively (Device #3). Mean peak values: G, 0.129 ± 0.021 nA; GG, 0.127 ± 0.016 nA; GGG, 0.127 ± 0.021 nA. e A flow diagram of amino acids identification using SAAINet. f Histograms of ΔI/I₀ obtained from nanopore experiments of G and A (Device #4) displayed as their fitting curves. Mean peak values: G, 0.229 ± 0.016; A, 0.295 ± 0.021. The average identification accuracy is 88.41%. g Graphical summary of precision, recall, and F1 score from SAAINet for the data in (f).