Fig. 8: Network rewiring during human fetal hematopoiesis. | Nature Communications

Fig. 8: Network rewiring during human fetal hematopoiesis.

From: Inference of cell type-specific gene regulatory networks on cell lineages from single cell omic datasets

Fig. 8

a k-means edge clusters of the top 1k edges (rows) across 11 cell clusters (columns). The edge confidence matrix was clustered into 21 clusters to identify common and divergent networks. The red intensity corresponds to the average confidence of edges in that cluster. Shown also are the number of edges in the edge cluster. b Top 5 regulators of each edge cluster. The size and brightness of the circle is proportional to the number of targets. Regulators mentioned in text are in red. c Top regulators associated with each cell cluster’s network in each topic for fine-grained lineage tree. Shown are only regulators that have at least 10 targets in any cell cluster. The brighter and larger the circle, the greater are the number of targets for the regulator. d Top regulators associated with each cell cluster’s network in each topic for coarse lineage tree. Shown are only regulators that have at least 10 targets in any cell cluster. The brighter and larger the circle, the greater are the number of targets for the regulator. For ease of interpretation only the top 10 regulators per topic are shown. The full list of regulators per topic are shown in Supplementary Fig. 31. Source data are provided as a Source Data file.

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